Are there any substitute chord changes to the Ray Noble compisition "Cherokee"?

Or does anyone have any hip reharmonization ideas?

You can always use tri-tone subs on the 2-5's.

Check out moneychord.com Lot's of good ideas for chord substitutions and music theory.

i agree with "Finemakesmusic"
for example, you could go [Bb ] [Fmin Bb7 Bmin E7] EbMaj7 etc